Intermittent Neuroleptic Therapy and Tardive Dyskinesia: A Literature Review
Abstract
Many authorities advocate neuroleptic-free periods for patients on chronic neuroleptics as a means of reducing the incidence or severity of tardive dyskinesia. This practice continues, despite the absence of any controlled clinical studies showing that intermittent therapy reduces the incidence or progression of tardive dyskinesia. After reviewing the pertinent clinical and animal literature, the authors conclude that there are few data to support the use of intermittent therapy as a means of reducing tardive dyskinesia and, in fact, evidence suggests it may increase the risk of persistent tardive dyskinesia.
Access content
To read the fulltext, please use one of the options below to sign in or purchase access.- Personal login
- Institutional Login
- Sign in via OpenAthens
- Register for access
-
Please login/register if you wish to pair your device and check access availability.
Not a subscriber?
PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.
Need more help? PsychiatryOnline Customer Service may be reached by emailing [email protected] or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).