The views expressed do not necessarily represent those of any organization with which the authors have been associated. Dr. Jerrell has received research grants from and served on national advisory boards for Eli Lilly and Company and Bristol-Myers Squibb. Dr. McIntyre has received honoraria for speaking and served as a consultant to Schering-Plough, received research grants from Eli Lilly, and served on advisory boards for AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Janssen-Ortho, Solvay-Wyeth, Eli Lilly, Lundbeck, Organon, Biovail, Pfizer, and Shire. Mr. Black reports no competing interests.