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Published Online:https://doi.org/10.1176/ps.40.8.849

The formulation of a depressive syndrome in the context of schizophrenia represents a microcosm of frontier areas in psychiatry: the psychological rehabilitation of psychotic patients, the differentiation between schizophrenic and mood disorders, and the biological bases of mood and affect. Such a syndrome represents a potential cause of morbidity and mortality for patients with schizophrenia and requires clinicians to seek greater understanding of its etiology.

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