Three brief overview papers from the Substance Abuse and Mental Health Services Administration (SAMHSA) provide information on how best to help people with co-occurring mental illness and substance use disorders. The reports are the last in a series of eight concise introductions that present information based on current research findings and best practices. The series, which was developed by SAMHSA's Co-occurring Center for Excellence (COCE), targets mental health and substance abuse treatment providers, administrators, and policy makers, although the reports also provide useful information to the general public.