Wayne's legacy derives from his holistic approach. We could divide his professional accomplishments into those relating to his research, clinical, and administrative work, but that would sever the vital connections. Wayne's early longitudinal studies of the course and symptoms of schizophrenia linked to his later efforts to develop a standardized battery to assess neuropsychological functioning. Both focus on understanding how persons with schizophrenia are living and experiencing the world. Wayne's focus on reliable and valid subtypes in schizophrenia was driven by his need to improve communication among people with schizophrenia, their families, their peers, their doctors and therapists, and researchers. Wayne's drive to connect was the foundation of all of his work.