• Life Sentences, by Alice Blanchard (New York, Warner, 2005), is a medical thriller whose main character, Daisy Hubbard, is a research scientist with the life goal to "be the first person in the world to cure a neurodegenerative disease using gene replacement therapy." The disease she seeks to cure is an inherited one, Stier-Zellar's disease—an autosomal recessive enzyme deficiency. It causes erosion of the myelin with gradual paralysis, mental retardation, and early death; symptoms generally manifest at two years of age, with death by eight years. (Daisy's only brother died from this disorder.) Unfortunately, the death and disorder in Daisy's family extends well beyond her brother. Her father died in a car crash when she was three years old, her mother has depression, and her sister has bipolar affective disorder or schizophrenia, "depending upon which doctor you talk to." As if that weren't enough, both Daisy and her sister were molested as children—her sister between ages five and nine. Her sister had her first psychotic break at age 13. Child molestation is not the only boundary transgression in Life Sentences. They show up everywhere. Sometimes they are central to the theme, and sometimes they are peripheral and rarely commented upon. Life Sentences is an engaging read, and I leave the plot to your discovery. Blanchard could have been much more informative, and it is too bad she didn't do a little bit more homework on mental illnesses. One unfortunate tendency Blanchard has is to use comparisons, similes, and metaphors that range from preposterous, through silly, to just simply confusing, providing no useful images to the reader—for example, "He had more culture than Yoplait" and, my favorite, "She stumbled around in a state of liquid suspension like a million-year-old swamp mummy." Life Sentences had the potential to be realistic as well as fun. It fails in the former, succeeds in the latter. The less you know about medicine, the better you'll like Life Sentences.—Jeffrey L. Geller, M.D., M.P.H., Worcester, Massachusetts