The book outlines epidemiologic data, possible mechanism of action, important physiologic and pharmacologic factors, and clinical issues related to caffeine and chocolate consumption. Included are the biophysiologic effects of caffeine on sleep, wakefulness, cognition, and mood. The effects on human behavior resulting from these biophysiologic effects are also precisely summarized. The information on the effect of caffeine on mood disorders, parkinsonism, ischemia, stroke, headache, and seizures are given special consideration. The book also addresses less commonly appreciated effects of caffeine on human stress and neurodevelopmental consequences of fetal exposure to caffeine. An interesting issue discussed in Coffee, Tea, Chocolate, and the Brain is the cerebral effect of noncaffeinated constituents of roasted coffee. Although the book focuses on providing information about caffeine, it outlines important information that is currently available about the biophysiologic and psychological effects of chocolate.