Most of the chapters discuss either new or old findings in a critical and unorthodox fashion—because the goal of this book is challenging the orthodox. Here I mention several interesting points. The neuroimaging section reviews the brain abnormalities in schizophrenia, but also the visualization of the cerebral alterations underlying hallucinations. The section on genetics discusses the important findings from the Iceland genetic study implicating neuregulin (1) as the first true susceptibility gene for schizophrenia. The section on epidemiology questions whether the environment can cause or contribute to schizophrenia. It also probes the possible risk and protective factors of schizophrenia—interestingly, smoking may reduce the risk of schizophrenia. Methamphetamine can induce psychosis that is almost identical to the positive syndrome, and cannabis abuse not only worsens schizophrenia but also can contribute to the onset of psychosis.