Four papers in this issue address the important topic of co-occurring general medical problems that affect the quality of life of people who are in treatment for mental and substance use disorders. In the first paper, Danson R. Jones, Ph.D., and colleagues note that persons with serious mental illness tend to be in poorer physical health than those who are not mentally ill. These authors examined the prevalence, severity, and co-occurrence of chronic general medical problems among persons with serious mental illness (see page 1250). In another study, Kimber P. Richter, Ph.D., M.P.H., and colleagues, determined the prevalence and types of nicotine dependence services offered in methadone treatment clinics in the United States (see page 1258). On a similar theme, Judith J. Prochaska, Ph.D., M.P.H., and her coauthors examined delivery of tobacco cessation services in a smoke-free inpatient psychiatric setting (see page 1265). Finally, in a brief report, Faith B. Dickerson, M.D., Ph.D., and her colleagues address the important issue of sexual and reproductive behaviors of persons with mental illness (see page 1299).