This well-written handbook provides a concise overview of many of the key domains of investigation into a devastating psychiatric disorder that, according to the authors, will be a major cause of disability worldwide by 2020, second only to ischemic heart disease. Currently, major depression is a common, costly, and recurrent psychiatric disorder associated with considerable morbidity and excessive mortality. Handbook of Depression provides an excellent overview of major progress in the treatment of depression over the last several decades of the 20th century. The main topics covered by the book include epidemiology, genetics, psychology, psychotherapy, and pharmacotherapy among children, adolescents, adults, and seniors, with promising implications for both prevention and treatment. Altogether 66 contributing authors from the United States, the United Kingdom, and Germany participated in the writing of this book.