As with other medical therapies, treatment with buprenorphine will cost money and raise questions about whether we can afford it and who should pay for it. Remarkably, many health care payers, including Medicaid programs in some states, still refuse to pay for methadone—even though overwhelming evidence exists that methadone treatment saves money by enabling people with a heroin addiction to hold jobs, steer clear of criminal activity, and avoid diseases, such as HIV.