As consumers turn increasingly to the World Wide Web to learn about health care, concerns have grown about the quality of available information. Web sites can be operated by virtually anyone, with minimal regulation, and no mechanisms are in place to correct misinformation. In this issue, Thomas L. Lissman, M.D., and James K. Boehnlein, M.D., review the quality of information produced by online searches for Web sites that discuss the treatment of depression. They entered the phrase "depression and treatment" into ten major Internet search engines and examined the first 20 sites generated by each. The authors found that the information is generally of poor quality, particularly among for-profit sites. Although many high-quality sites discussing depression are available, only two appeared among the first 20 items in these searches (see page 1046).