In this first issue of 2001, Psychiatric Services initiates a year-long series of articles on implementing evidence-based practices across a number of treatment settings and with a variety of populations. As journal editor John A. Talbott, M.D., notes in Taking Issue (page 7), a major focus of the journal this year will be on helping clinicians change what may no longer be working. Evidence-based practices are those for which clinical services research has found substantial evidence of effectiveness and which therefore should be routinely offered in clinical settings. As William C. Torrey, M.D., and his colleagues point out, such practices have not found their way into most mental health systems. These authors describe a project to help clinicians and administrators initiate changes in their behaviors and in treatment systems to ensure that persons with serious mental illness benefit from services that have been shown to work (page 45). Robert E. Drake, M.D., Ph.D., and Howard H. Goldman, M.D., Ph.D., are editors of the series. Future issues will feature articles on implementing evidence-based practices in supported employment, for patients with dual diagnoses, and for children's services, among other topics.