The Lieberman review focuses on the last decade—the introduction of atypical antipsychotics for schizophrenia and selective serotonin reuptake inhibitors (SSRIs) for depression. But, as the authors point out, progress has not been unalloyed. The clinical benefit of atypical antipsychotics is small to modest, with little evidence of widespread dramatic gains in quality of life. The clearest advantage is reduction of extrapyramidal side effects, but adverse effects such as weight gain, diabetes, and hyperlipidemia threaten to take their place. By all accounts, SSRIs are no more effective than tricyclic antidepressants. They are easier and safer to administer and may generate better medication compliance, but they too are associated with many troublesome side effects.