In the late 1970s mental health professionals were beginning to recognize that a new generation of chronic patients was emerging, young adults who had spent relatively little time in psychiatric hospitals but presented challenging problems for staff in community programs. This month we continue our retrospective look at important developments in psychiatry over the past 50 years by reprinting a seminal article on young adult chronic patients by Bert Pepper, M.D., and associates from the July 1981 issue (see page 989). In a related commentary and analysis, Francine Cournos, M.D., and Stephanie Le Melle, M.D., note that the themes covered in the article came to dominate discourse about how to meet the needs of this new patient group (see page 996)…. In the Taking Issue column, Burton V. Reifler, M.D., M.P.H., points out that meeting the needs of a challenging new cohort of patients—those over age 65 with no previous history of serious and persistent mental illness—is the most important demographic imperative facing psychiatry today (see page 961).