Traditional antipsychotic medications were instrumental in the deinstitutionalization movement, and for some patients these agents successfully attenuated the positive symptoms of psychosis and permitted supported community living. However, the extensive side effects associated with the dopaminergic agents had a significant negative impact on most patients' functioning. Much attention has been focused on movement disorders as a major adverse outcome. However, the most common physiological aberrations associated with traditional antipsychotic medications may be their neuroendocrine properties, including hyperprolactinemia, amenorrhea, and infertility among female recipients. As we discussed in a recent psychopharmacology column in this journal (February 1998), endocrine effects of antipsychotics have only recently received significant attention.