I would not characterize this book as a breakthrough; it is largely a restatement of what has been said, and said well, in several other books (1,2,3,4), including one by Torrey himself (5). Yet by its very provocativeness, the volume provides a needed incentive for change. As noted by Daniel Kevles (6) who reviewed this book for the New York Times Book Review, "Like all polemics Out of the Shadows should be read with caution, but its analyses deserve attention."