The study explored patterns of risk behavior and knowledge about HIV and AIDS among patients in an inpatient psychiatric facility in south India. Fifty-nine consecutive patients admitted to a state psychiatric hospital were interviewed using a semistructured questionnaire. Fifty-one percent had a history of recent risk behavior, and 86 percent had inadequate knowledge about AIDS. The most common high-risk behavior was unprotected heterosexual intercourse with a high-risk partner. There was no correlation between knowledge and high-risk behavior. The findings underscore the need to specifically tailor intervention programs.