Three cases in which patients who were taking fluoxetine for relief of
depression showed patterns of abnormal movements suggestive of tardive
dyskinesia are presented. In the first case, abnormal facial movements
began four weeks after fluoxetine was added to doxepin and lithium and
remitted after fluoxetine was discontinued. In the second case, abnormal
movements of the mouth and hands were noticed four years after the patient
started taking fluoxetine and continued to be present a year after
withdrawal of the medication. In the third case, orofacial dyskinesia that
had remitted after withdrawal of sertraline and paroxetine and reappeared
with fluoxetine was still present eight months after fluoxetine was
withdrawn.
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