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Article   |    
Clinical Significance of Inpatient Family Intervention: Conclusions From a Clinical Trial
Ira D. Glick; John F. Clarkin; Gretchen L. Haas; James H. Spencer, Jr.
Psychiatric Services 1993; doi:
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This work was supported in part by biomedical research support grant RR05396 from the National Institutes of Health to Cornell University Medical Center, grant MH-34466 from the National Institute of Mental Health, and a grant from the Norman and Rosita Winston Foundation. The authors thank Kathleen Stenbeck for help in data analysis and Nina Schooler, Ph. D., for review of the manuscript.

Payne Whitney Clinic, Cornell University Medical College, 525 East 68th Street, New York, New York 10021

Cornell University Medical College in New York City; New York Hospital

University of Pittsburgh

1993 by the American Psychiatric Association

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Objective: To test whether the statistically significant results of a randomized clinical trial of an inpatient family intervention were clinically significant for hospital practice, the authors reanalyzed outcome data using a measure of clinical significance based on the extent to which patients bad recovered during the course of the intervention. Methods: A total of 169 hospitalized subjects and their families were randomly assigned to a psychoeducational inpatient family intervention or to a comparison group. Patient and family outcome measures were assessed at admission, discharge, and six and 18 months after admission. Analyses of statistically significant differences in outcome suggested that inpatient family intervention was effective for certain patient subgroups identified by gender and diagnosis. Global Assessment Scale scores two or more standard deviations above the pretreatment ( admission) mean were used as indicators for clinically significant improvement. Results: The reanalysis confirmed that inpatient family intervention was associated with clinically significant improvement at discharge, especially for female patients and patients with chronic schizophrenia and bipolar disorder. These effects were maintained six months after admission before attenuating at 18 months. Conclusions: inpatient family intervention results in clinically meaningful outcomes for certain subgroups of patients ad their families.

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