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Three Phases of Clozapine Treatment and Phase-Specific Issues for Patients and Families
Marilyn Kotcher; Thomas E. Smith
Psychiatric Services 1993; doi:
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New York Hospital-Cornell Medical Center, Westchester Division, 2 1 Bloomingdale Road, White Plains, New York 10605

New York Hospital, Westchester Division; Cornell University Medical College in New York City

1993 by the American Psychiatric Association

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Abstract

Based on the authors' experience with more than 40 patients with treatment-refractory schizophrenia, they describe three phases of clozapine treatment. Phase-speufic responses of patients and their families during clozapine trials often resemble their reactions during adaptation to chronic schizophrenia. Because the effectiveness of clozapine treatment has been so widely reported, many reactions are based on families' cure and rescue fantasies that resurface and intensify after having previously been worked through. Extreme, paradoxical, and problematic reactions, such as conflicts arising from patients' improved functioning, can threaten the viability of the clozapine trial and must be carefully managed by the therapist. The authors recommend specific treatment approaches for the different phases of the clozapine trial, including family therapy and psychoeducation throughout the trial and an approach based on object relations during the final phase.

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