A stepwise approach to clinical management of lithium-induced polyuria is suggested. Nonpharmacologic interventions such as dose reduction and change in dosage distribution should be tried first. If such measures prove inadequate, potassium supplementation may be tried. Pharmacologic intervention focuses primarily on amiloride, although amiloride-hydrochlorothiazide combinations are occasionally necessary. Finally, indomethacin is a newer resource available, and one recommended only for cases in which immediate normalization of polyuria is necessary.