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Article   |    
Substance Use Disorders in Patients With Chronic Fatigue
Henry R. Kranzler; Peter Manu; Victor M. Hesselbrock; Thomas J. Lane; Dale A. Matthews
Psychiatric Services 1991; doi:
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This work was supported in part by grant AA07290 from the National Institute on Alcohol Abuse and Alcoholism.

Department of Psychiatry at the University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, Connecticut 06030

School's Department of Medicine, The Medical Service of the Veterans Affairs Medical Center in Newington, Connecticut

School's Department of Medicine

1991 by the American Psychiatric Association

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A high prevalence of mood disorders has been found among persons with chronic fatigue. The comorbidity of mood disorders and substance use disorders has long been recognized. In this study, the preyalence of substance use disorders among 100 patients with chronic fatigue was examined. Twentyeight patients met DSM-III-R criteria for a lifetime diagnosis of substance abuse or dependence; ten of these patients had a current diagnosis. Forty-nine patients had no history of substance abuse or dependence but bad other lifetime psychiatric diagnoses. Twenty-three patients bad no history of substance abuse or psychiatric illness. No differences in demographic characteristics or in the features of chronic fatigue were found among the three groups. Patients with chronic fatigue who had a lifetime history of a substance use disorder reported more lifetime depressive symptoms and were more likely to have had suicidal ideation or attempts.

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