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Article   |    
Effects of Six Months of Clozapine Treatment on the Quality of Life of Chronic Schizophrenic Patients
Herbert Y. Meltzer; Sarah Burnett; Bijan Bastani; Luis F. Ramirez
Psychiatric Services 1990; doi:
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The research reported here was supported in part by U.S. Public Health Service grants MH-41684 and MH-41594 and grants from the Cleveland Foundation, the John Pascal Sawyer Memorial Foundation, the Prentice Foundation, and Sandoz, Inc. It was also partly supported by a PHS Research Career Scientist Award (MH-47808) to Dr. Meltzer.

Case Western Reserve University School of Medicine in Cleveland

University Hospital in Cleveland

1990 by the American Psychiatric Association

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Abstract

The effect of approximately six months of treatment with clozapine on the quality of life of 38 treatment-resistant schizophrenic patients was prospectively studied in an open trial. The Quality of Life Scale was used to provide an objective measure of changes in patients' psychosocial functioning. Significant improvement was noted on all four factors of the scale. The ratings tended to be negatively correlated with ratings on the Brief Psychiatric Rating Scale at baseline and at six months. At 12 months, patients' rehospitalization rate was reduced by 83 percent and was independent of the six-month quality-of-life ratings.

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