0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

Article   |    
Five-Center Study Clarifies Use of Lithium, Imipramine for Recurrent Affective Disorders
Robert F. Prien
Psychiatric Services 1984; doi:
View Author and Article Information

National Institute of Mental Health; Room 1OC-06, NIMH, 5600 Fishers Lane, Rockville, Maryland 20857

1984 by the American Psychiatric Association

text A A A
PDF of the full text article.
Abstract

This collaborative study suggests the following guidelines for practice:Lithium is the treatment of choice for the long-term preventive treatment of bipolar disorder. The use of imipramine for this group of patients is not recommended because of the high risk of a manic episode.There appears to be no advantage to combining imipramine with lithium for maintenance treatment of bipolar patients.Lithium therapy is especially indicated for bipolar patients whose last episode is manic.For unipolar patients whose index episode is of moderate Severity, lithium and imipramine are equally effective. However, the results strongly suggest that lithium is relatively ineffective in preventing severe unipolar depression.There is no advantage in combining lithium and imipramine in preventive maintenance treatment of unipolar depression.Because of its strong antimanic properties, lithium may be of value in maintenance treatment of unipolar disorder where there is a suspicion of a latent bipolar disorder or first-degree relatives with a history of bipolar illness.

Abstract Teaser
Figures in this Article

Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Articles
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 12.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 23.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 1.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 45.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 5.  >
Topic Collections
Psychiatric News
APA Guidelines
PubMed Articles