The book begins by addressing the origin of polypharmacy in psychiatry, dating back to the mid-19th century. The history of this "taboo" is explained in exquisite depth in the first chapter, whose authors set forth to review the practice of polypharmacy from its historical roots through the psychopharmacological revolution and to the present day. The book includes major reviews and offers much needed interdisciplinary insight into polypsychopharmacological issues pertaining to many of the major DSM diagnoses, such as schizophrenia, bipolar disorder, and posttraumatic stress disorder. Approaches to polypharmacy are discussed from the perspective of the disease, the type of drug, and the population—for example, high-risk populations, children, and medically compromised individuals. Issues surrounding "rational" as well as "irrational" polypharmacy are addressed in each of these contexts.