In May 1996 the Center for Mental Health Research on AIDS convened a national conference of experts to review existing research and design a research agenda on the impact of AIDS on persons with severe mental illness. In response to recommendations stemming from the conference, the Five-Site Health and Risk Study Research Committee conducted a study to gather information on the epidemiology of HIV, hepatitis B, hepatitis C, and other blood-borne infections in relatively large samples of persons with severe mental illness in Connecticut, Maryland, New Hampshire, and North Carolina. In a special section of six articles in this issue of Psychiatric Services, guest editor Stanley D. Rosenberg, Ph.D., and other members of the research committee present the results of this multisite study, covering prevalence rates of blood-borne infections among persons with severe mental illness, sexual and drug-related risk factors, gender differences in prevalence and risk, and access to medical care among at-risk individuals. The implications of the committee's findings for the care of this patient population and for public health policy are also discussed (see page 827).