As a young psychiatric resident, I often found myself disillusioned with the field of psychiatry in general because of the lack of biological substance in certain areas. In my opinion, Defining Psychopathology in the 21st Century has helped close the rift that existed, in my mind at least, between psychiatry and the other branches of medicine, offering a discussion on the future of the field that was very biologically based. In the past, psychiatric illness has been defined by syndromes. The authors of this book state that accurately delineating these clinical syndromes will make it easier to elucidate their etiology and that research in genetics and neuroimaging will help to tie these syndromes to the underlying abnormality.