Mathew weaves the anatomy and functions of neuroscience with theories of perception and Indian philosophies of consciousness. He explores historical drug use as a means to spirituality. He discusses the concept of self and its possible anatomical counterpart in the dominant hemisphere of the brain. He integrates nondominant hemisphere functions with art, music, nature, spirituality, and pleasure, including pleasure of the experience of devotion, meditation, and the uncontaminated consciousness or God.