Psychoeducational materials can be disseminated at minimal expense through the use of distance technologies, offering an opportunity for prevention. The objective of this project was to develop and evaluate a psychoeducational computer program designed to prevent depressive symptoms. The program was accessible through the Internet or by touch-tone telephone. A total of 786 participants were randomly assigned either to the preventive intervention or to an information-only control condition. Over a three-month follow-up period, no differences between the groups were observed. However, three of the target variables (cognitive style, activity level, and sleep quality) were found to be strong predictors of whether a participant had an episode of major depression during the follow-up period.