The past few years have seen increased emphasis on translational research, which takes findings generated by randomized controlled trials—efficacy studies—and translates them into treatments for patients who are seen in nonresearch settings. Two articles in this issue of the journal describe approaches to the design of sound effectiveness research. Both describe hybrid models that retain essential features of efficacy research while expanding the research questions to address real-world issues, such as cost-effectiveness and diversity in treatment populations. In the first article, Peter P. Roy-Byrne, M.D., and his colleagues review the rationale for decisions they made in designing one of the first translational studies of the treatment of anxiety disorder in primary care (see page 327). Next, Kathleen M. Carroll, Ph.D., and Bruce J. Rounsaville, M.D., propose a hybrid model for enhancing the scientific yield of effectiveness research in substance abuse treatment (see page 333). In Taking Issue, Kenneth Minkoff, M.D., and Christie A. Cline, M.D., M.B.A., call on behavioral health researchers to learn how to build and organize systems that are capable of adopting innovative technologies in order to ensure the success of science-to-service initiatives (see page 275).