The book contains 23 chapters. The first reviews the roots and evolution of the concept of bipolar disorder since Hippocrates' days. Chapters 2 through 5 review the spectrum concept of bipolar disorder, mixed bipolar disorder, rapid cycling, and bipolar schizo-affective disorder. Chapters 6 through 8 discuss bipolar disorder in special populations, including among women who are pregnant, in the postpartum period, or in menopause; among adolescents; and among the elderly. In chapters 9 and 10 the authors nicely review the interface between temperament, personality types, and bipolar disorder. The next six chapters address important topics such as the comorbidity, genetics, epidemiology, and biology of bipolar disorder. Three chapters cover the somatic treatments used in bipolar disorder, including lithium, anticonvulsants, antipsychotics, and antidepressants. The remaining chapters cover prognosis, diagnostic boundaries, and the economic impact of bipolar disorder.