To the Editor: Depression is an important public health problem with significant costs both to individuals and society. In 2003, the U.S. lifetime prevalence of major depressive disorder was 16.2% (1). Depression is the leading cause of disability (2), with an estimated cost of $83.1 billion in the United States in 2000 (3). As of 2009, the U.S. Preventive Services Task Force (USPSTF) recommends “screening adults for depression in clinical practices that have systems in place to assure accurate diagnosis, effective treatment, and follow-up” (4). In light of these recommendations, the primary aim of the study reported here was to estimate the rate of depression screening in the U.S. outpatient office setting.