Engaging patients in mental health treatment can be seen as series of linked steps—from encouraging individuals to seek care to ensuring that they remain in treatment long enough to receive an effective “dose.” A broken link often means a poor clinical outcome. Because research has consistently shown that the current system is less effective at engaging members of underserved racial-ethnic minority groups, strengthening engagement is an appropriate target for reducing disparities. In the lead article, Alejandro Interian, Ph.D., and colleagues report findings from a review of current interventions that employ strategies to enhance engagement. The systematic review found ten randomized trials in which patients from underserved racial-ethnic groups made up at least half the sample. Collaborative care for depression was the only approach that could be designated as efficacious for engagement. Ingredients include patient choice of a primary care–based treatment, use of a depression care manager who monitors symptoms and adherence, and psychiatrist consultation with the primary care physician. The review found many problems with the design of recent studies—problems that were highlighted more than a decade ago in the Surgeon General’s report on culture, race, and ethnicity and that, as the authors note, “curtail our ability to assess the evidence base for improving engagement among the very populations who are disproportionately affected by this issue” (page 212). In Taking Issue, Jo Anne Sirey, Ph.D., describes the challenge of “embracing engagement with all its complexity” and the need for investigators to build strong partnerships with other community providers (page 205).