As public mental health beds become scarce, the needs of the smaller number of people residing in these facilities have become more challenging and complex. Most evidence-based practices were neither developed nor validated with clinical samples having the complex patterns of comorbidity often seen in state psychiatric facilities. For example, a hospital clinician may be called to treat an individual with treatment-resistant schizophrenia who has also experienced an acquired brain injury, struggles with chronic pain, has abused narcotics for years, has experienced repeated traumas, engages in aggressive behaviors, lacks family support, and has never been employed.