This month’s issue highlights important research milestones regarding e-health technologies and their potential to enhance access to psychosocial interventions and improve outcomes for persons with mental disorders. Hunkeler and colleagues conducted a randomized controlled trial of an Internet-delivered chronic care model for persons with chronic depression enrolled in a staff-model health maintenance organization. The program involves a Web-based self-management program supported by electronic medical record–enhanced panel management and provider decision support. Deen and coauthors report on a national assessment of telehealth use in the U.S. Department of Veterans Affairs, which found substantial increases in individual and group telepsychotherapy encounters in recent years. These e-health technologies have great potential to extend the reach of psychosocial interventions beyond the clinic walls, especially for persons in rural settings or who are reluctant to seek mental health specialty care.