The potential for e-health psychosocial interventions to improve patient outcomes will remain unrealized without a concerted effort by health plans, payers, and providers to transform care from a reactive, acute care–based system to a more proactive system based on the chronic care model. Emerging efforts to redesign health systems, such as accountable care organizations and health homes under Medicaid expansion, have the potential to make this transformation a reality. These initiatives should encourage the use of bundled payments to support the infrastructure of the chronic care model, meaningful use requirements for electronic medical records, and patient-centered care strategies. However, these efforts will also need to be coupled with implementation strategies to get e-health psychosocial interventions off the academic shelf and into the hands of consumers. Overall, a combined top-down and bottom-up strategy in which e-health is one of several components will be needed to improve adoption of effective mental health treatments and ultimately improve outcomes for this patient group.