Several authors with years of expertise in treating mood disorders contribute chapters on various topics, including pharmacotherapy for depression, psychotherapy for depression, approaches to sleep hygiene, nutrition, concomitant substance abuse, and medical comorbidities. Treatment-resistant depression is examined in multiple populations, with separate chapters devoted to adolescents, college students, pregnant women, and the geriatric population. Each chapter is written by a different set of authors with different styles, leading to a mosaic of topics. For the most part, the book maintains its focus in proposing multiple treatment modalities in different populations. However, the chapter on the medical care model for bipolar disorder is discontinuous with the treatment-resistant depression theme and would have been better placed in a separate volume.