Having an ill infant who requires care in a neonatal intensive care unit (NICU) is a significant stressor for parents. Ideals about healthy babies are shattered, and parents may be uprooted from work and family in order to spend time with their critically ill infants. The NICU environment itself is fast-paced and frequented by unexpected turns of events. Parents may experience depression, anxiety, and hostility, and taken together with problematic parent-infant interactions, these reactions may affect the infant's length of stay in the NICU. Parents often do not proactively seek help for their own problems because of barriers such as insurance, stigma, and the desire to spend their available time with their infants. Parents' needs may "fall through the cracks" in the usual system, simply because of fragmentation of care provided by obstetrics, pediatrics, and psychiatry. The NICU itself presents an opportune location for psychoeducation, diagnosis, and treatment of maternal and paternal mental health issues. NICU staff can also benefit from psychiatric support. Staff bond with the infants in their care, and when conditions gravely worsen, staff too need to grieve.