Many of the studies in this issue focus on general medical care for people with serious mental illness. In recent years advocates have worked hard to raise awareness of the 25-year disparity in life expectancy between these individuals and other Americans—a disparity not explained by unnatural causes such as suicide or accidents. Largely as a result of these efforts, general medical care for this group, which was an "orphan topic" a decade ago, has now moved into the mainstream of research and policy initiatives, notes Benjamin G. Druss, M.D., M.P.H., in his Taking Issue commentary (page 833). In the lead article Daniel W. Bradford, M.D., M.P.H., and colleagues present results of their analysis of U.S. population data for more than 156,000 adults, which indicates that persons with psychotic or bipolar disorders have markedly more difficulty obtaining care than persons without mental disorders (page 847). In a study involving extensive interviews with 119 older persons with schizophrenia and a comparison group without the disorder, Ipsit V. Vahia, M.D., and colleagues found that the former group received less adequate treatment for four common medical disorders (page 853). In the third article Ray Block, Ph.D., and a group of Canadian researchers present a financial analysis that sought to determine whether integrating specialized mental health services with general health services, which was done in the province of Alberta in 2003, increased or decreased spending on mental health care as a proportion of all health care spending (page 860). When general medical practitioners in Norway refer patients to their local community mental health center, they continue to monitor patients' treatment. Oyvind Andresen Bjertnaes, M.A., and colleagues conducted a survey of all general practitioners in Norway and found that many reported negative experiences with the centers; their responses indicated areas for improving care and collaboration (page 864). In addition to these articles, the four brief reports in this issue focus on general medical care. The first presents results from a national survey of community mental health centers about the availability of on-site medical screening and medical services (page 917). The second examines perceptions of barriers to medical care among veterans with serious mental illness (page 921). The third reveals a very high rate of psychiatric conditions in a large cohort of veterans with epilepsy (page 925). The final brief report looks at use of cancer-screening services by persons with serious mental illness in a California county (page 929).