CATIE was supported by grant N01-MH-90001 from the National Institute of Mental Health (NIMH). The project was carried out by principal investigators from the University of North Carolina, Duke University, the University of Southern California, the University of Rochester, and Yale University in association with Quintiles, Inc.; the program staff of the Division of Interventions and Services Research of NIMH; and investigators from 56 U.S. sites (CATIE Study Investigators Group).The investigators are Lawrence Adler, M.D., Clinical Insights, Glen Burnie, Md.; Mohammed Bari, M.D., Synergy Clinical Research, Chula Vista, Calif.; Irving Belz, M.D., Tri-County Mental Health and Mental Retardation Services, Conroe, Tex.; Raymond Bland, M.D., Southern Illinois University School of Medicine, Springfield; Thomas Blocher, M.D., Mental Health and Mental Retardation Authority of Harris County, Houston; Brent Bolyard, M.D., Cox North Hospital, Springfield, Mo.; Alan Buffenstein, M.D., Queen's Medical Center, Honolulu; John Burruss, M.D., Baylor College of Medicine, Houston; Matthew Byerly, M.D., University of Texas Southwestern Medical Center at Dallas; Jose Canive, M.D., Albuquerque Department of Veterans Affairs (VA) Medical Center, Albuquerque, N.M.; Stanley Caroff, M.D., Behavioral Health Service, Philadelphia; Charles Casat, M.D., Behavioral Health Center, Charlotte, N.C.; Eugenio Chavez-Rice, M.D., El Paso Community Mental Health and Mental Retardation Center, El Paso, Tex.; John Csernansky, M.D., Washington University School of Medicine, St. Louis, Mo.; Pedro Delgado, M.D., University Hospitals of Cleveland, Cleveland, Ohio; Richard Douyon, M.D., VA Medical Center, Miami; Cyril D'Souza, M.D., Connecticut Mental Health Center, New Haven; Ira Glick, M.D., Stanford University School of Medicine, Palo Alto, Calif.; Donald Goff, M.D., Massachusetts General Hospital, Boston; Silvia Gratz, M.D., Eastern Pennsylvania Psychiatric Institute, Philadelphia; George T. Grossberg, M.D., St. Louis University School of Medicine-Wohl Institute, St. Louis. Mo.; Mahlon Hale, M.D., New Britain General Hospital, New Britain, Conn.; Mark Hamner, M.D., Medical University of South Carolina and VA Medical Center, Charleston; Richard Jaffe, M.D., Belmont Center for Comprehensive Treatment, Philadelphia; Dilip Jeste, M.D., University of California-San Diego, and VA Medical Center, San Diego; Anita Kablinger, M.D., Louisiana State University Health Sciences Center, Shreveport; Ahsan Khan, M.D., University of Kansas School of Medicine, Wichita; Steven Lamberti, M.D., University of Rochester Medical Center, Rochester, N.Y.; Michael T. Levy, M.D., Staten Island University Hospital, Staten Island, N.Y.; Jeffrey Lieberman, M.D., University of North Carolina School of Medicine, Chapel Hill; Gerald Maguire, M.D., University of California-Irvine, Orange; Theo Manschreck, M.D., Corrigan Mental Health Center, Fall River, Mass.; Joseph McEvoy, M.D., Duke University Medical Center, Durham, N.C.; Mark McGee, M.D., Appalachian Behavioral Healthcare, Athens, Ohio; Herbert Meltzer, M.D., Vanderbilt University Medical Center, Nashville, Tenn.; Alexander Miller, M.D., University of Texas Health Science Center at San Antonio; Del D. Miller, M.D., University of Iowa, Iowa City; Henry Nasrallah, M.D., University of Cincinnati Medical Center, Cincinnati, Ohio; Charles Nemeroff, M.D., Ph.D., Emory University School of Medicine, Atlanta, Ga.; Stephen Olson, M.D., University of Minnesota Medical School, Minneapolis; Gregory F. Oxenkrug, M.D., St. Elizabeth's Medical Center, Boston; Jayendra Patel, M.D., University of Massachusetts Health Care, Worcester; Frederick Reimher, M.D., University of Utah Medical Center, Salt Lake City; Silvana Riggio, M.D., Mount Sinai Medical Center-Bronx VA Medical Center, Bronx, N.Y.; Samuel Risch, M.D., University of California-San Francisco, San Francisco; Bruce Saltz, M.D., Henderson Mental Health Center, Boca Raton, Fla.; Thomas Simpatico, M.D., Northwestern University, Chicago; George Simpson, M.D., University of Southern California Medical Center, Los Angeles; Michael Smith, M.D., Harbor-UCLA Medical Center, Torrance, Calif.; Roger Sommi, Pharm.D., University of Missouri, Kansas City; Richard M. Steinbook, M.D., University of Miami School of Medicine, Miami; Michael Stevens, M.D., Valley Mental Health, Salt Lake City, Utah; Andre Tapp, M.D., VA Puget Sound Health Care System, Tacoma, Wash.; Rafael Torres, M.D., University of Mississippi, Jackson; Peter Weiden, M.D., SUNY Downstate Medical Center, Brooklyn, N.Y.; and James Wolberg, M.D., Mount Sinai Medical Center, New York City.