Six reports in this month's issue address treatment of affective disorders. Lisa V. Rubenstein, M.D., M.S.P.H., and colleagues describe a new instrument that predicted six-month outcomes among nearly 1,500 primary care patients treated for major depression (page 1049). In a study of 1,801 elderly patients with depression in primary care, Patricia A. Areán, Ph.D., and colleagues found that those with low incomes derived greater treatment benefits in a collaborative model that involved a team approach and a depression care specialist (page 1057). A research group led by Evette J. Ludman, Ph.D., found favorable outcomes among depressed patients whose treatment involved telephone monitoring and participation in peer-led or professionally led groups (page 1065). An analysis of Medicaid claims data for nearly 13,500 patients with bipolar disorder by Jeff J. Guo, B.Pharm., Ph.D., and colleagues, found that treatment of the disorder accounted for only 30% of costs, whereas treatment for key comorbidities, such as drug use disorders and cerebral-vascular disease, accounted for 70% (page 1073). Michelle Munson, Ph.D., and colleagues held a series of focus groups for case managers, who spoke of their desire to help depressed elderly clients in community long-term care and their lack of training and resources to do so (page 1124). Findings from a study of 10,545 depressed veterans reported in Datapoints by John F. McCarthy, Ph.D., and colleagues indicate low rates of guideline-concordant care (page 1035).