Even though tablet splitting can greatly reduce medication costs, some clinicians question whether patients with psychosis can follow splitting instructions. After a region of the Veterans Affairs health system recommended this approach for risperidone prescribing, Ellen M. Weissman, M.D., M.P.H., and Cornelia Dellenbaugh, M.P.H., retrospectively investigated adherence among nearly 2,000 patients. The results provided some assurance that the practice does not lead to poor clinical outcomes, although a subgroup of patients initially experienced problems with crumbled tablets and some needed extra clinic appointments (page 201). In Taking Issue, Peter Weiden, M.D., wonders whether such pill-splitting initiatives will ultimately have adverse effects on adherence by steering pharmaceutical companies away from flat pricing (page 163). In another study of adherence, by John D. Piette, Ph.D., and colleagues, veterans with schizophrenia and comorbid illnesses who were taking several medications at once—for schizophrenia, for diabetes, and for hypertension—were found to have significant differences in adherence across medications (page 207).