Five articles in this month's issue examine the prevalence of anxiety disorders and their impact on people's lives. In a sample of more than 1,000 older adults in Brooklyn, New York, Carl I. Cohen, M.D., and colleagues found prevalence rates of 2.3 and 13.3 percent for syndromal and subsyndromal anxiety, respectively. In the past year, 23 percent of the first group and 12 percent of the second group had sought mental health care (page 1719). To identify potential medications for future effectiveness trials targeting the secondary prevention of posttraumatic stress disorder (PTSD), Douglas Zatzick, M.D., and Peter P. Roy-Byrne, M.D., documented the types of medications prescribed for seriously injured patients at discharge from a level 1 trauma center (page 1726). In a study of 324 primary care patients with major depressive disorder, Dinesh Mittal, M.D., and colleagues found that nearly 70 percent had comorbid anxiety disorders and that those with generalized anxiety disorder or PTSD experienced significant impairments in health-related quality of life over and above those related to depression (page 1731). Povl Munk-Jørgensen, M.D., Ph.D., and colleagues, examined data from 756 general practitioners and nearly 9,000 patients to determine rates of generalized anxiety disorder in Denmark, Norway, Sweden, and Finland. In more than a third of cases the physicians did not detect the disorder (page 1738). In a qualitative study Snigdha Mukherjee, Ph.D., and colleagues analyzed transcribed interviews with 21 economically disadvantaged patients who received cognitive-behavioral therapy for panic disorder and found that adherence depended on a day-to-day decision-making process based on self-monitoring and on beliefs about the treatment's efficacy (page 1745).