The book opens with a series of revelatory quotes from the authors' clinical experience at an HIV clinic that capture the essence of working with patients who have multiple diagnoses—for example, "Thank you for saving my life, Dr. Treisman. Can I have a dollar?"; "Drug treatment is a good concept, but it doesn't work for me"; and "My way might be crazy, but it's how I've always done it." Nine equally lively chapters follow, interspersed with case presentations. The chapters discuss patients with HIV infection who also suffer from major depression, dementia, psychosis, personality disorders, substance abuse, chronic pain, sexual dysfunction, or any mixture of these or other HIV-related mental health problems. Glenn J. Treisman, M.D., Ph.D., is known for his ability to engage an audience in the management of challenging patients, and he and his coauthor, Andrew F. Angelino, M.D., invite the reader to learn these techniques.