The mind is what the brain does." So wrote Massachusetts Institute of Technology psychologist Steven Pinker in his celebrated 1997 book, How the Mind Works (1). Today, and in the wake of the ongoing genetics revolution, Pinker's former student Gary Marcus takes a stab at answering the lofty question, What do our minds owe to nature, and what to nurture? Until recently, we knew relatively little about how genes work and what they bring to the biological structures that underlie the mind. Marcus reminds us that now, 50 years after the discovery of the molecular structure of DNA, we are for the first time in a position to understand directly DNA's contribution to the mind.