Late-Life Depression is devoted to the epidemiology, phenomenology, psychobiology, and consequences of late-life depression and describes current attitudes to treatment. The contributors to this book point out that the current DSM criteria have not been modified to reflect the clinical features unique to the depressed elderly, who tend to report more somatic and cognitive symptoms than affective symptoms. Neurocognitive presentation of depression among elderly individuals who are experiencing forgetfulness and distractability is a part of the phenomenology of depression. Depression may also play a role in the development of vascular disease. Elevations in the hypothalamic-pituitary-adrenal axis play an integral role in the expression and outcome of depression as well as in comorbid diseases among the elderly. Subclinical endocrinopathies—for example, mild testosterone deficiency—are etiologically important in the development of subthreshold neuropsychiatric problems.