The articles in this special section of Psychiatric Services represent the findings from that conference. The first article, by Mark P. McGovern, Ph.D., and his colleagues, summarizes the theory and empirical research on relapse prevention in the general population of persons with substance use disorder. The next two articles, by Haiyi Xie, Ph.D., and colleagues and Angela L. Rollins, Ph.D., and colleagues, offer quantitative perspectives on predicting relapse of substance use disorder among clients with dual diagnoses who appear to be in stable remission. The next two articles—by Kristin E. Davis, Ph.D., and Sheila J. O'Neill, L.C.S.W., and by Maxine Harris, Ph.D., and her colleagues—provide qualitative views of relapse. As expected, the quantitative studies identify more distal and fixed risk factors, whereas the qualitative studies permit a more proximal and dynamic view. In the final article, my colleagues and I attempt to distill the findings and draw inferences for future studies in this area. Other presentations from the conference were omitted because they overlapped with the findings presented in these articles, were considered too preliminary by their presenters, or had already been submitted or published elsewhere.