A large proportion of this issue of Psychiatric Services is devoted to reports on various multisite services effectiveness trials. Stephen Leff, Ph.D., and his coauthors studied the effects of job development and job support on the acquisition and retention of competitive employment by persons with mental illness. Their results are reported on page 1237. In another article, Dr. Leff and his colleagues describe a five-site study that compared Medicaid managed behavioral health programs and fee-for-service programs for adults with serious mental illness in terms of service use and quality, satisfaction, and symptoms and functioning (page 1245). Three additional articles stem from the Women, Co-occurring Disorders, and Violence Study (WCDVS), the first major federal effort to address the lack of appropriate services for women with co-occurring mental health and substance use disorders who have a history of physical or sexual abuse. In the first of these articles, Joseph P. Morrissey, Ph.D., and his colleagues present the results of this nine-site quasi-experimental study at the final 12-month follow-up and answer the question of whether positive effects at six months were maintained at 12 months (see page 1213). Marisa Elena Domino, Ph.D., and her coauthors then discuss the 12-month costs associated with the services received by the women in the study (page 1223). Finally, Chanson D. Noether, M.A., and associates describe the overall design of the WCDVS and provide suggestions for future research (page 1233). And in Taking Issue, APA President Steven S. Sharfstein, M.D., laments the erosion of federal support for multisite services effectiveness trials, noting that the studies reported in this issue of the journal emphasize the impact of and the need for continued investment in the acquisition of knowledge by the field of psychiatry (page 1185).