Doonan introduces us to 16 wacky chicks, each one of whom is more eccentric and outrageous than the last. The mother of all wacky chicks is Spider Fawke, a six-foot-tall, 48-year-old insect collector and clothing designer who lives with 38 lizards and a four-inch tarantula in a 600-square-foot apartment. Some wacky chicks you may be familiar with—Amy Sedaris, writer and star of the Comedy Central series Strangers With Candy, who lives in an apartment with a forest motif, including a liquor cabinet carved out of a tree trunk, which was designed for her pet rabbit, Tattle-tail. Brigid Berlin, Andy Warhol muse and pug lover, is another wacky chick. But a majority of the wacky chicks are women you've never heard of. They are women with larger-than-life personalities who, in Doonan's opinion, are the epitome of feminism. They offer advice on fashion and style, beauty, dating, and finding your inner wacky chick. They are chock-full of attitude and unconventional wisdom; they dare to be different, and they love every minute of it.